Advancement of Nucleic Acid Biosensors Based on Morpholino
نویسندگان
چکیده
Morpholino has drawn considerable attention as a result of its advantageous properties. In the past few decades, morpholino has demonstrated in applications as being the premier knockdown tool in developmental biology because of its cytosolic delivery in the embryos through micro-injection. Morpholino has outstanding affinity for nucleic acids and the destabilizing effect of mismatches in morpholinocontaining heterodimers is higher than in a DNA or RNA double strand. Therefore, morpholino-based nucleic acid biosensors have high sensitivity and specificity for nucleic acid detection. In this review, the characteristics of morpholino are briefly introduced, followed by highlights of nucleic acid biosensors based on morpholino, including fabrication, analytical characteristics and biological applications.
منابع مشابه
Design of Biosensors Based Transition-Metal Dichalcogenide for DNA-base Detection: A First-Principles Density Functional Theory Study
The main function purpose of nanobiosensors is to sense a biologically specific material and the kind of sensing platform and doping engineering has been an emerging topic and plays an important role in monolayer molybdenum disulfide (mMoS2). In this paper, we theoretically reveal the electronic structures of mMoS2 doped by 3d transition metals. Furthermore, adsorption of nucleic acid [Adenine ...
متن کاملAdvancement in electrochemical DNA-biosensors for GMOs detection: A review
Genetically modified organisms (GMOs) are plants or animals whose genetic make-up has been transformed by recombinant DNA technology, which has new features such as resistance to herbicides, virus and insect. Recently, genetic modification of food products has increased in order to reduce world poverty and hunger and increase food production However, the impact of GMOs on the human health is a ...
متن کاملNanobiosensors and fluorescence based biosensors: An overview
A biosensor can sense biological elements after interaction with the recognition element. The signal produced due to interaction of the analyte with its biochemical element is transduced by a transducer and detected by appropriate modes. The miniaturization of these biosensors at the nano level using nanostructures as a platform for sensing the analyte or its detection is called a nanobiosensor...
متن کاملNanobiosensors and fluorescence based biosensors: An overview
A biosensor can sense biological elements after interaction with the recognition element. The signal produced due to interaction of the analyte with its biochemical element is transduced by a transducer and detected by appropriate modes. The miniaturization of these biosensors at the nano level using nanostructures as a platform for sensing the analyte or its detection is called a nanobiosensor...
متن کاملDirect DNA Immobilization onto a Carbon Nanotube Modified Electrode: Study on the Influence of pH and Ionic Strength
Over the past years, DNA biosensors have been developed to analyze DNA interaction and damage that have important applications in biotechnological researches. The immobilization of DNA onto a substrate is one key step for construction of DNA electrochemical biosensors. In this report, a direct approach has been described for immobilization of single strand DNA onto carboxylic acid-functionalize...
متن کامل